Ictal bradycardia in a patient with a hypothalamic hamartoma: A stereo-EEG study

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Kahane P, Di Leo M, Hoffmann D, and Munari C (1999) Ictal bradycardia in a patient with a hypothalamic hamartoma: A stereo-EEG study. Epilepsia 40:4 522–7.

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Abstract: Little is known about bradycardia and cardiac asystole which occur during partial epileptic seizures, especially whether they relate to ictal involvement of well-defined cortical areas. Several reports based on simultaneous electrocardiographic and intracranial depth electroencephalographic monitoring have shown that either the fronto-orbital cortex or the amygdalohippocampal complex could be responsible for such cardiac variations. We performed stereo-EEG recordings in a patient with refractory localization-related epilepsy associated with a hypothalamic hamartoma. We found that other cortical areas, such as the frontocentral region and the temporal neocortex, can contribute to the genesis of ictal bradyarrhythmia. Second, the lesion per se, although located within the hypothalamus, is not involved with this phenomenon.

Keywords: Ictal bradycardia, Partial epileptic seizures, Hypothalamic hamartoma, Intracerebral electrodes, Epilepsy, surgery


  • Single-case report of patient with hypothalamic hamartoma and ictal bradycardia. Intracerebral EEG localized epileptiform activity to other foci at the time of the bradycardia. Numerous EKG/EEG traces from individual seizures show variable timing of arrhythmia relative to seizure onset.


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