Sudden unexpected death in epilepsy (SUDEP): Update and reflections

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Nashef L and Ryvlin P (2009) Sudden unexpected death in epilepsy (SUDEP): Update and reflections. Neurol Clin 27:4 1063–74.

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Abstract: SUDEP remains a significant clinical problem, which, in the authors' opinion, is to some extent potentially preventable. Research needs to focus on interventions that may alter risk. Some wide-ranging suggestions for future developments that in time can translate to clinical practice have been presented. These suggestions, the authors believe, give rise to cautious optimism.

Keywords: Epilepsy, SUDEP, Definitions, AEDs, Mortemus, Supervision


  • Review of incidence and risk factor data. Touches on evidence for and against risk elevation due to certain AED, genetic susceptibility, Discussion of role of serotonin in maintaining oscillatory breathing is valuable.


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