Cardiac causes of sudden unexpected death in children and their relationship to seizures and syncope: Genetic testing for cardiac electropathies: Difference between revisions
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''Ackerman MJ (2005) Cardiac causes of sudden unexpected death in children and their relationship to seizures and syncope: Genetic testing for cardiac electropathies. Semin Pediatr Neurol 12:1 52–8.'' | ''Ackerman MJ (2005) Cardiac causes of sudden unexpected death in children and their relationship to seizures and syncope: Genetic testing for cardiac electropathies. Semin Pediatr Neurol 12:1 52–8.'' | ||
'''[http://ac.els-cdn.com/S1071909105000197/1-s2.0-S1071909105000197-main.pdf?_tid=5434cee4-6692-11e7-8ae5-00000aab0f26&acdnat=1499816612_f56b3b1bb7278504055a868404ae3c4f Link to Article]''' | |||
'''Abstract:'''The sentinel descriptions of congenital long QT syndrome (LQTS) under the eponyms of Jervell and Lange-Nielsen syndrome and Romano-Ward syndrome were provided in 1957 and the early 1960s. In 1995, the discipline of cardiac channelopathies was birthed formally with the landmark discoveries of cardiac channel mutations as the pathogenic basis for LQTS. Over the past decade, the discipline has expanded considerably being comprised of at least a dozen distinct heritable arrhythmia syndromes, several disease-susceptibility genes, and hundreds of implicated mutations. Previously confined to the purview of research testing, diagnostic genetic testing for several channelopathies is now available for routine clinical use. | '''Abstract:'''The sentinel descriptions of congenital long QT syndrome (LQTS) under the eponyms of Jervell and Lange-Nielsen syndrome and Romano-Ward syndrome were provided in 1957 and the early 1960s. In 1995, the discipline of cardiac channelopathies was birthed formally with the landmark discoveries of cardiac channel mutations as the pathogenic basis for LQTS. Over the past decade, the discipline has expanded considerably being comprised of at least a dozen distinct heritable arrhythmia syndromes, several disease-susceptibility genes, and hundreds of implicated mutations. Previously confined to the purview of research testing, diagnostic genetic testing for several channelopathies is now available for routine clinical use. | ||
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'''Keywords:''' Long QT Syndrome, genetic testing, ion channels, sudden death | '''Keywords:''' Long QT Syndrome, genetic testing, ion channels, sudden death | ||
=Comments and Context= | |||
*Review of long QT syndromes and genetics. | |||
Revision as of 00:55, 12 July 2017
Ackerman MJ (2005) Cardiac causes of sudden unexpected death in children and their relationship to seizures and syncope: Genetic testing for cardiac electropathies. Semin Pediatr Neurol 12:1 52–8.
Abstract:The sentinel descriptions of congenital long QT syndrome (LQTS) under the eponyms of Jervell and Lange-Nielsen syndrome and Romano-Ward syndrome were provided in 1957 and the early 1960s. In 1995, the discipline of cardiac channelopathies was birthed formally with the landmark discoveries of cardiac channel mutations as the pathogenic basis for LQTS. Over the past decade, the discipline has expanded considerably being comprised of at least a dozen distinct heritable arrhythmia syndromes, several disease-susceptibility genes, and hundreds of implicated mutations. Previously confined to the purview of research testing, diagnostic genetic testing for several channelopathies is now available for routine clinical use.
Keywords: Long QT Syndrome, genetic testing, ion channels, sudden death
Comments and Context
- Review of long QT syndromes and genetics.