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This controlled case‐series observation study first described the association between SUDEP risk and lamotrigine treatment of idiopathic epilepsy. Various mechanisms have been proposed for this potential association including arrhythmogenic cardiac effects and possibility of less efficacy of lamotrigine in some specific idiopathic epilepsy syndromes. A 2011 Combined analysis of all case–control studies from the United States, Sweden, Scotland, and England concluded that risk factors that were statistically significant included: frequency of generalized tonic–clonic seizures (GTCS), use of polytherapy, duration of epilepsy, young age at onset, gender, symptomatic etiology, and [[lamotrigine therapy | This un-controlled case‐series observation study first described the association between SUDEP risk and lamotrigine treatment of idiopathic epilepsy. Various mechanisms have been proposed for this potential association including arrhythmogenic cardiac effects and possibility of less efficacy of lamotrigine in some specific idiopathic epilepsy syndromes. A 2011 Combined analysis of all case–control studies from the United States, Sweden, Scotland, and England concluded that risk factors that were statistically significant included: frequency of generalized tonic–clonic seizures (GTCS), use of polytherapy, duration of epilepsy, young age at onset, gender, symptomatic etiology, and [[lamotrigine therapy | ||
]]In univariate analysis, lamotrigine therapy was associated with significantly increased risk for SUDEP among individuals with idiopathic generalized epilepsy. | ]]In univariate analysis, lamotrigine therapy was associated with significantly increased risk for SUDEP among individuals with idiopathic generalized epilepsy. | ||
Revision as of 04:50, 23 February 2020
Namespace: Template
Name: Reference
Purpose: Use this template for standard reference pages on this site.
Parameters:
- reference - reference for the article (e.g., Annegers JF (1997) United States perspective on definitions and classifications. Epilepsia. 1997 Nov;38(11 Suppl):S9-12.) - url - URL for the full article (e.g., https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1528-1157.1997.tb06137.x) - abstract - the article's abstract - keywords - a comma-delimited list of key words (e.g., classification, postmortem, definitions) - context - context of the article - comments - comments about the article
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Context
This un-controlled case‐series observation study first described the association between SUDEP risk and lamotrigine treatment of idiopathic epilepsy. Various mechanisms have been proposed for this potential association including arrhythmogenic cardiac effects and possibility of less efficacy of lamotrigine in some specific idiopathic epilepsy syndromes. A 2011 Combined analysis of all case–control studies from the United States, Sweden, Scotland, and England concluded that risk factors that were statistically significant included: frequency of generalized tonic–clonic seizures (GTCS), use of polytherapy, duration of epilepsy, young age at onset, gender, symptomatic etiology, and [[lamotrigine therapy ]]In univariate analysis, lamotrigine therapy was associated with significantly increased risk for SUDEP among individuals with idiopathic generalized epilepsy.
Comments
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