https://sudepwiki.pathology.jhmi.edu/index.php?title=Amygdala_sclerosis_in_sudden_and_unexpected_death_in_epilepsy&feed=atom&action=historyAmygdala sclerosis in sudden and unexpected death in epilepsy - Revision history2024-03-29T05:29:54ZRevision history for this page on the wikiMediaWiki 1.35.0https://sudepwiki.pathology.jhmi.edu/index.php?title=Amygdala_sclerosis_in_sudden_and_unexpected_death_in_epilepsy&diff=1264&oldid=prevAlano at 17:02, 17 June 20192019-06-17T17:02:37Z<p></p>
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<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">''Thom M, Griffin B, Sander JW, and Scaravilli F (1999) Amygdala sclerosis in sudden and unexpected death in epilepsy. Epilepsy Res 37:1 53–62.''</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">{{Reference</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">'''[https://ac.els-cdn.com/S0920121199000315/1-s2.0-S0920121199000315-main.pdf?_tid</del>=<del class="diffchange diffchange-inline">c65e118c-ced0-11e7-a592-00000aacb362&acdnat=1511278353_908ce71eabc6a76cd1cbff35eb52f3d0 Link to Article]'''</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|reference</ins>=</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">'''Abstract:''' Sclerosis of the amygdala is a not uncommon finding in patients with chronic epilepsy. The amygdala has efferent connections</del>, <del class="diffchange diffchange-inline">via the central nuclei</del>, <del class="diffchange diffchange-inline">to cardioregulatory centres </del>in <del class="diffchange diffchange-inline">the medulla. Experimental studies have suggested that damage to the central nucleus may be of functional significance in patients with </del>sudden and unexpected death in epilepsy <del class="diffchange diffchange-inline">(SUDEP) in particular with regard to their susceptibility to cardiac arrhythmias</del>. <del class="diffchange diffchange-inline">We investigated this possibility by carrying out a quantitative immunohistochemical analysis of the patterns of neuronal loss and gliosis in three amygdala subnuclei (central, basal and lateral) in post mortem material from 15 SUDEP cases and seven normal controls. We identified significant neuronal loss in the medial division of the lateral amygdaloid nucleus in SUDEP cases but not in central or basal nuclei. These patterns of cell loss in the amygdala do not differ from previous studies in both humans and animal models of chronic epilepsy suggesting that there is not a specific pattern of amygdaloid sclerosis in SUDEP patients which could implicate a functional role for this nucleus in the mechanism of the sudden death</del>.</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Thom M, Griffin B</ins>, <ins class="diffchange diffchange-inline">Sander JW</ins>, <ins class="diffchange diffchange-inline">and Scaravilli F (1999) Amygdala sclerosis </ins>in sudden and unexpected death in epilepsy. <ins class="diffchange diffchange-inline">Epilepsy Res 37:1 53–62</ins>.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">'''Keywords:''' Amygdala; Epilepsy; Sudden death</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|url=</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>=<del class="diffchange diffchange-inline">Context</del>=</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">https://ac.els-cdn.com/S0920121199000315/1-s2.0-S0920121199000315-main.pdf?_tid</ins>=<ins class="diffchange diffchange-inline">c65e118c-ced0-11e7-a592-00000aacb362&acdnat=1511278353_908ce71eabc6a76cd1cbff35eb52f3d0</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|abstract=</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Sclerosis of the amygdala is a not uncommon finding in patients with chronic epilepsy. The amygdala has efferent connections, via the central nuclei, to cardioregulatory centres in the medulla. Experimental studies have suggested that damage to the central nucleus may be of functional significance in patients with sudden and unexpected death in epilepsy (SUDEP) in particular with regard to their susceptibility to cardiac arrhythmias. We investigated this possibility by carrying out a quantitative immunohistochemical analysis of the patterns of neuronal loss and gliosis in three amygdala subnuclei (central, basal and lateral) in post mortem material from 15 SUDEP cases and seven normal controls. We identified significant neuronal loss in the medial division of the lateral amygdaloid nucleus in SUDEP cases but not in central or basal nuclei. These patterns of cell loss in the amygdala do not differ from previous studies in both humans and animal models of chronic epilepsy suggesting that there is not a specific pattern of amygdaloid sclerosis in SUDEP patients which could implicate a functional role for this nucleus in the mechanism of the sudden death.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|keywords=</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Amygdala; Epilepsy; Sudden death</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|context</ins>=</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control ([[Cardiac and respiratory correlations with unit discharge in human amygdala and hippocampus|Frysinger and Harper, 1989]]), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by study of postmortem tissue specimens. Neuronal loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP. More extensive discussion of potential involvement of the amygdala in SUDEP is in the Context section at [[Respiratory modulation of neuronal discharge in the central nucleus of the amygdala during sleep and waking states|Zhang et al., 1986]].</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control ([[Cardiac and respiratory correlations with unit discharge in human amygdala and hippocampus|Frysinger and Harper, 1989]]), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by study of postmortem tissue specimens. Neuronal loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP. More extensive discussion of potential involvement of the amygdala in SUDEP is in the Context section at [[Respiratory modulation of neuronal discharge in the central nucleus of the amygdala during sleep and waking states|Zhang et al., 1986]].</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>=<del class="diffchange diffchange-inline">Comments=</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|comments</ins>=</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">}}</ins></div></td></tr>
</table>Alanohttps://sudepwiki.pathology.jhmi.edu/index.php?title=Amygdala_sclerosis_in_sudden_and_unexpected_death_in_epilepsy&diff=1219&oldid=prevDnauen1 at 01:16, 26 August 20182018-08-26T01:16:17Z<p></p>
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</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l9" >Line 9:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=Context=</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=Context=</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control ([[Cardiac and respiratory correlations with unit discharge in human amygdala and hippocampus|Frysinger and Harper, 1989]]), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by study of postmortem tissue specimens. Neuronal loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP. More extensive discussion of potential involvement of the amygdala in SUDEP is in the <del class="diffchange diffchange-inline">context </del>section at [[Respiratory modulation of neuronal discharge in the central nucleus of the amygdala during sleep and waking states|Zhang et al., 1986]].</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control ([[Cardiac and respiratory correlations with unit discharge in human amygdala and hippocampus|Frysinger and Harper, 1989]]), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by study of postmortem tissue specimens. Neuronal loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP. More extensive discussion of potential involvement of the amygdala in SUDEP is in the <ins class="diffchange diffchange-inline">Context </ins>section at [[Respiratory modulation of neuronal discharge in the central nucleus of the amygdala during sleep and waking states|Zhang et al., 1986]].</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=Comments=</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=Comments=</div></td></tr>
</table>Dnauen1https://sudepwiki.pathology.jhmi.edu/index.php?title=Amygdala_sclerosis_in_sudden_and_unexpected_death_in_epilepsy&diff=1218&oldid=prevDnauen1 at 01:15, 26 August 20182018-08-26T01:15:53Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:15, 26 August 2018</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control ([[Cardiac and respiratory correlations with unit discharge in human amygdala and hippocampus|Frysinger and Harper, 1989]]), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by study of postmortem tissue specimens. Neuronal loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP.</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control ([[Cardiac and respiratory correlations with unit discharge in human amygdala and hippocampus|Frysinger and Harper, 1989]]), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by study of postmortem tissue specimens. Neuronal loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP<ins class="diffchange diffchange-inline">. More extensive discussion of potential involvement of the amygdala in SUDEP is in the context section at [[Respiratory modulation of neuronal discharge in the central nucleus of the amygdala during sleep and waking states|Zhang et al., 1986]]</ins>.</div></td></tr>
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</table>Dnauen1https://sudepwiki.pathology.jhmi.edu/index.php?title=Amygdala_sclerosis_in_sudden_and_unexpected_death_in_epilepsy&diff=1217&oldid=prevDnauen1 at 01:06, 26 August 20182018-08-26T01:06:48Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:06, 26 August 2018</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=Context=</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=Context=</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control (Frysinger <del class="diffchange diffchange-inline">et al.</del>), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by <del class="diffchange diffchange-inline">investigating </del>postmortem tissue specimens. <del class="diffchange diffchange-inline">Neural </del>loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP.</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*In light of the influence of the central nucleus of the amygdala on autonomic control (<ins class="diffchange diffchange-inline">[[Cardiac and respiratory correlations with unit discharge in human amygdala and hippocampus|</ins>Frysinger <ins class="diffchange diffchange-inline">and Harper, 1989]]</ins>), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by <ins class="diffchange diffchange-inline">study of </ins>postmortem tissue specimens. <ins class="diffchange diffchange-inline">Neuronal </ins>loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP.</div></td></tr>
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</table>Dnauen1https://sudepwiki.pathology.jhmi.edu/index.php?title=Amygdala_sclerosis_in_sudden_and_unexpected_death_in_epilepsy&diff=736&oldid=prevYcarmen1: Created page with "''Thom M, Griffin B, Sander JW, and Scaravilli F (1999) Amygdala sclerosis in sudden and unexpected death in epilepsy. Epilepsy Res 37:1 53–62.'' '''[https://ac.els-cdn.com..."2017-11-21T15:30:42Z<p>Created page with "''Thom M, Griffin B, Sander JW, and Scaravilli F (1999) Amygdala sclerosis in sudden and unexpected death in epilepsy. Epilepsy Res 37:1 53–62.'' '''[https://ac.els-cdn.com..."</p>
<p><b>New page</b></p><div>''Thom M, Griffin B, Sander JW, and Scaravilli F (1999) Amygdala sclerosis in sudden and unexpected death in epilepsy. Epilepsy Res 37:1 53–62.''<br />
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'''[https://ac.els-cdn.com/S0920121199000315/1-s2.0-S0920121199000315-main.pdf?_tid=c65e118c-ced0-11e7-a592-00000aacb362&acdnat=1511278353_908ce71eabc6a76cd1cbff35eb52f3d0 Link to Article]'''<br />
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'''Abstract:''' Sclerosis of the amygdala is a not uncommon finding in patients with chronic epilepsy. The amygdala has efferent connections, via the central nuclei, to cardioregulatory centres in the medulla. Experimental studies have suggested that damage to the central nucleus may be of functional significance in patients with sudden and unexpected death in epilepsy (SUDEP) in particular with regard to their susceptibility to cardiac arrhythmias. We investigated this possibility by carrying out a quantitative immunohistochemical analysis of the patterns of neuronal loss and gliosis in three amygdala subnuclei (central, basal and lateral) in post mortem material from 15 SUDEP cases and seven normal controls. We identified significant neuronal loss in the medial division of the lateral amygdaloid nucleus in SUDEP cases but not in central or basal nuclei. These patterns of cell loss in the amygdala do not differ from previous studies in both humans and animal models of chronic epilepsy suggesting that there is not a specific pattern of amygdaloid sclerosis in SUDEP patients which could implicate a functional role for this nucleus in the mechanism of the sudden death.<br />
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'''Keywords:''' Amygdala; Epilepsy; Sudden death<br />
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=Context=<br />
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*In light of the influence of the central nucleus of the amygdala on autonomic control (Frysinger et al.), the possibility of damage to the amygdala as a precursor to SUDEP was investigated by investigating postmortem tissue specimens. Neural loss was significant in the lateral nucleus but not the central or basal nuclei. This pattern was reported in previous studies of chronic epilepsy and is not specific to SUDEP.<br />
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=Comments=</div>Ycarmen1