Epilepsy: A ‘going ape’ model for SUDEP?
Striano P and Zara F (2009) Epilepsy: A ‘going ape’ model for SUDEP? Nat Rev Neurol 5:12 639–40.
Abstract: Despite growing interest in both the clinical and scientific aspects of sudden unexpected death in epilepsy (SUDEP), knowledge about the disease mechanisms remains limited. The epileptic baboon—the first natural nonhuman primate model of SUDEP—offers a potential model to evaluate the genetic factors and pathophysiology underlying this mysterious condition.
- Comment on Szabó et al. Discusses many aspects of SUDEP concisely. Discusses potential causes central apnea and neurogenic pulmonary edema together as ‘respiratory compromise,’ though the underlying processes are likely to be distinct.