https://sudepwiki.pathology.jhmi.edu/index.php?title=Heart_rate_and_EKG_changes_in_102_seizures:_Analysis_of_influencing_factors&feed=atom&action=history
Heart rate and EKG changes in 102 seizures: Analysis of influencing factors - Revision history
2024-03-28T22:01:25Z
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Alano at 17:32, 17 June 2019
2019-06-17T17:32:34Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:32, 17 June 2019</td>
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<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">''Opherk C, Coromilas J, and Hirsch L(2002) Heart rate and EKG changes in 102 seizures: Analysis of influencing factors. Epilepsy research 52:2 117–127.''</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">{{Reference</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">'''[https://ac.els-cdn.com/S0920121102002152/1-s2.0-S0920121102002152-main.pdf?_tid</del>=<del class="diffchange diffchange-inline">2fc2ffcc-b2be-11e7-9f5f-00000aab0f6c&acdnat=1508191737_493518010126bc43e508e5299ff03c7c Link to Article]'''</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|reference</ins>=</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">'''Abstract:''' PURPOSE: Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in patients with epilepsy. Since cardiac arrhythmia may be a responsible factor</del>, <del class="diffchange diffchange-inline">we sought to determine the prevalence of significant EKG abnormalities during and immediately after epileptic seizures</del>, and <del class="diffchange diffchange-inline">to identify risk factors for these changes. METHODS: We retrospectively assessed changes in heart rate </del>(<del class="diffchange diffchange-inline">HR</del>) and <del class="diffchange diffchange-inline">the occurrence of </del>EKG <del class="diffchange diffchange-inline">abnormalities </del>in 102 seizures <del class="diffchange diffchange-inline">(71 non-generalized, 31 generalized) from 41 patients using video-EKG-EEG recordings. RESULTS</del>: <del class="diffchange diffchange-inline">The majority </del>of <del class="diffchange diffchange-inline">seizures (101/102; 99%) led to an increase in HR</del>. <del class="diffchange diffchange-inline">EKG abnormalities (other than sinus tachycardia) were noted in 22/102 (21.5%) seizures overall. Most EKG changes were benign, but potentially serious changes occurred in 6/102 (6%) seizures and 4/41 (10%) patients. These included ST-depression (5 seizures in 3 patients) and T-wave inversion (1 seizure). Ictal HR was higher (P<0.03) and EKG-abnormalities were more common (P<0.05) in generalized compared to non-generalized seizures. Ictal EKG abnormalities were seen in 35% of generalized seizures, including potentially serious changes in 13%. There was a trend towards higher risk of ictal EKG abnormalities when seizures arose from sleep or from the left hemisphere, when MRI showed evidence of hippocampal sclerosis, and when ictal HR was higher. Age and seizure duration had no effect on the occurrence of EKG abnormalities. CONCLUSION</del>: <del class="diffchange diffchange-inline">We conclude that ictal EKG abnormalities other than sinus tachycardia are not unusual, especially in generalized seizures. These findings may be relevant to the phenomenon of SUDEP</del>.</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Opherk C</ins>, <ins class="diffchange diffchange-inline">Coromilas J</ins>, and <ins class="diffchange diffchange-inline">Hirsch L</ins>(<ins class="diffchange diffchange-inline">2002</ins>) <ins class="diffchange diffchange-inline">Heart rate </ins>and EKG <ins class="diffchange diffchange-inline">changes </ins>in 102 seizures: <ins class="diffchange diffchange-inline">Analysis </ins>of <ins class="diffchange diffchange-inline">influencing factors</ins>. <ins class="diffchange diffchange-inline">Epilepsy research 52</ins>:<ins class="diffchange diffchange-inline">2 117–127</ins>.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">'''Keywords:''' EKG; Epilepsy; SUDEP; Sudden death; Autonomic; Arrhythmia</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|url=</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>=<del class="diffchange diffchange-inline">Context</del>=</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">https://ac.els-cdn.com/S0920121102002152/1-s2.0-S0920121102002152-main.pdf?_tid</ins>=<ins class="diffchange diffchange-inline">2fc2ffcc-b2be-11e7-9f5f-00000aab0f6c&acdnat</ins>=<ins class="diffchange diffchange-inline">1508191737_493518010126bc43e508e5299ff03c7c</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>=<del class="diffchange diffchange-inline">Comments</del>=</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|abstract</ins>=</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">PURPOSE: Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in patients with epilepsy. Since cardiac arrhythmia may be a responsible factor, we sought to determine the prevalence of significant EKG abnormalities during and immediately after epileptic seizures, and to identify risk factors for these changes. METHODS: We retrospectively assessed changes in heart rate (HR) and the occurrence of EKG abnormalities in 102 seizures (71 non-generalized, 31 generalized) from 41 patients using video-EKG-EEG recordings. RESULTS: The majority of seizures (101/102; 99%) led to an increase in HR. EKG abnormalities (other than sinus tachycardia) were noted in 22/102 (21.5%) seizures overall. Most EKG changes were benign, but potentially serious changes occurred in 6/102 (6%) seizures and 4/41 (10%) patients. These included ST-depression (5 seizures in 3 patients) and T-wave inversion (1 seizure). Ictal HR was higher (P<0.03) and EKG-abnormalities were more common (P<0.05) in generalized compared to non-generalized seizures. Ictal EKG abnormalities were seen in 35% of generalized seizures, including potentially serious changes in 13%. There was a trend towards higher risk of ictal EKG abnormalities when seizures arose from sleep or from the left hemisphere, when MRI showed evidence of hippocampal sclerosis, and when ictal HR was higher. Age and seizure duration had no effect on the occurrence of EKG abnormalities. CONCLUSION: We conclude that ictal EKG abnormalities other than sinus tachycardia are not unusual, especially in generalized seizures. These findings may be relevant to the phenomenon of SUDEP.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|keywords</ins>=</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">EKG; Epilepsy; SUDEP; Sudden death; Autonomic; Arrhythmia</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|context=</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|comments=</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">}}</ins></div></td></tr>
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Alano
https://sudepwiki.pathology.jhmi.edu/index.php?title=Heart_rate_and_EKG_changes_in_102_seizures:_Analysis_of_influencing_factors&diff=603&oldid=prev
Ycarmen1: Created page with "''Opherk C, Coromilas J, and Hirsch L(2002) Heart rate and EKG changes in 102 seizures: Analysis of influencing factors. Epilepsy research 52:2 117–127.'' '''[https://ac.el..."
2017-10-16T22:06:56Z
<p>Created page with "''Opherk C, Coromilas J, and Hirsch L(2002) Heart rate and EKG changes in 102 seizures: Analysis of influencing factors. Epilepsy research 52:2 117–127.'' '''[https://ac.el..."</p>
<p><b>New page</b></p><div>''Opherk C, Coromilas J, and Hirsch L(2002) Heart rate and EKG changes in 102 seizures: Analysis of influencing factors. Epilepsy research 52:2 117–127.''<br />
<br />
'''[https://ac.els-cdn.com/S0920121102002152/1-s2.0-S0920121102002152-main.pdf?_tid=2fc2ffcc-b2be-11e7-9f5f-00000aab0f6c&acdnat=1508191737_493518010126bc43e508e5299ff03c7c Link to Article]'''<br />
<br />
'''Abstract:''' PURPOSE: Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in patients with epilepsy. Since cardiac arrhythmia may be a responsible factor, we sought to determine the prevalence of significant EKG abnormalities during and immediately after epileptic seizures, and to identify risk factors for these changes. METHODS: We retrospectively assessed changes in heart rate (HR) and the occurrence of EKG abnormalities in 102 seizures (71 non-generalized, 31 generalized) from 41 patients using video-EKG-EEG recordings. RESULTS: The majority of seizures (101/102; 99%) led to an increase in HR. EKG abnormalities (other than sinus tachycardia) were noted in 22/102 (21.5%) seizures overall. Most EKG changes were benign, but potentially serious changes occurred in 6/102 (6%) seizures and 4/41 (10%) patients. These included ST-depression (5 seizures in 3 patients) and T-wave inversion (1 seizure). Ictal HR was higher (P<0.03) and EKG-abnormalities were more common (P<0.05) in generalized compared to non-generalized seizures. Ictal EKG abnormalities were seen in 35% of generalized seizures, including potentially serious changes in 13%. There was a trend towards higher risk of ictal EKG abnormalities when seizures arose from sleep or from the left hemisphere, when MRI showed evidence of hippocampal sclerosis, and when ictal HR was higher. Age and seizure duration had no effect on the occurrence of EKG abnormalities. CONCLUSION: We conclude that ictal EKG abnormalities other than sinus tachycardia are not unusual, especially in generalized seizures. These findings may be relevant to the phenomenon of SUDEP.<br />
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'''Keywords:''' EKG; Epilepsy; SUDEP; Sudden death; Autonomic; Arrhythmia<br />
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=Context=<br />
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=Comments=</div>
Ycarmen1