Prevalence of cardiac conduction disturbances during carbamazepine treatment: Preliminary data

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Spina E, Kenneback G, Bergfeldt L, and Tomson T(1987) Prevalence of cardiac conduction disturbances during carbamazepine treatment: Preliminary data. Funct Neurol 2:4 563–7.

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Abstract: Twenty-five epileptic patients chronically treated with carbamazepine underwent 24 h electrocardiogram (ECG) monitoring in order to evaluate the prevalence of cardiac conduction abnormalities. Plasma levels of carbamazepine and its metabolite, carbamazepine-10,11-epoxide, were determined by liquid chromatography. Six patients had mild ECG abnormalities. These patients did not differ from the others with respect to plasma concentrations of the drug and its metabolite.

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  • Early study of effect of CBZ on cardiac function. 25 patients on CBZ underwent 24-hour EKG. Mild EKG abnormalities were found in 6 patients, but blood levels of CBZ or a metabolite were not systematically different from values in the remaining patients.

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