Prevalence of cardiac conduction disturbances during carbamazepine treatment: Preliminary data

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Spina E, Kenneback G, Bergfeldt L, and Tomson T(1987) Prevalence of cardiac conduction disturbances during carbamazepine treatment: Preliminary data. Funct Neurol 2:4 563–7.

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Abstract: Twenty-five epileptic patients chronically treated with carbamazepine underwent 24 h electrocardiogram (ECG) monitoring in order to evaluate the prevalence of cardiac conduction abnormalities. Plasma levels of carbamazepine and its metabolite, carbamazepine-10,11-epoxide, were determined by liquid chromatography. Six patients had mild ECG abnormalities. These patients did not differ from the others with respect to plasma concentrations of the drug and its metabolite.

Context

  • Early study of effect of CBZ on cardiac function. 25 patients on CBZ underwent 24-hour EKG. Mild EKG abnormalities were found in 6 patients, but blood levels of CBZ or a metabolite were not systematically different from values in the remaining patients.

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