Difference between revisions of "Pulmonary afferent and central influences on respiratory phase-switching in the cat"

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''Cohen MI (1981) Pulmonary afferent and central influences on respiratory phase-switching in the cat. Can J Physiol Pharmacol 59:7 675–82.''
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'''[https://www.ncbi.nlm.nih.gov/pubmed/?term=Pulmonary+afferent+and+central+influences+on+respiratory+phase-switching+in+the+cat Link to Article]'''
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'''Abstract:''' A striking feature of the mammalian respiratory rhythm generator is the abruptness of the transitions between the inspiratory (I) and expiratory (E) phases ("phase-switching"). Although reciprocal inhibitory actions between I and E neurons are important for maintaining the alternation of respiratory phases, phase-switching actions are probably produced by recurrent inhibitory neuronal loops acting within each phase. The operation of such negative feedback circuits has been studied using two types of experimental input: (a) activation of pulmonary stretch receptors by lung inflation, which shortens the I phase and prolongs the E phase, and (b) electrical stimulation in the rostral pontine "pneumotaxic center" region, which can produce premature I leads to E or E leads to I switching, depending on stimulation site. These inputs produce diverse effects on discharges of various types of medullary respiratory neuron; analysis of such observations has led to hypotheses about the possible roles of different neuron populations in phase-switching.
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Cohen MI (1981) Pulmonary afferent and central influences on respiratory phase-switching in the cat. Can J Physiol Pharmacol 59:7 675–82.
  
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https://www.ncbi.nlm.nih.gov/pubmed/?term=Pulmonary+afferent+and+central+influences+on+respiratory+phase-switching+in+the+cat
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A striking feature of the mammalian respiratory rhythm generator is the abruptness of the transitions between the inspiratory (I) and expiratory (E) phases ("phase-switching"). Although reciprocal inhibitory actions between I and E neurons are important for maintaining the alternation of respiratory phases, phase-switching actions are probably produced by recurrent inhibitory neuronal loops acting within each phase. The operation of such negative feedback circuits has been studied using two types of experimental input: (a) activation of pulmonary stretch receptors by lung inflation, which shortens the I phase and prolongs the E phase, and (b) electrical stimulation in the rostral pontine "pneumotaxic center" region, which can produce premature I leads to E or E leads to I switching, depending on stimulation site. These inputs produce diverse effects on discharges of various types of medullary respiratory neuron; analysis of such observations has led to hypotheses about the possible roles of different neuron populations in phase-switching.
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Latest revision as of 13:52, 17 June 2019


Cohen MI (1981) Pulmonary afferent and central influences on respiratory phase-switching in the cat. Can J Physiol Pharmacol 59:7 675–82.

Link to Article

Abstract: A striking feature of the mammalian respiratory rhythm generator is the abruptness of the transitions between the inspiratory (I) and expiratory (E) phases ("phase-switching"). Although reciprocal inhibitory actions between I and E neurons are important for maintaining the alternation of respiratory phases, phase-switching actions are probably produced by recurrent inhibitory neuronal loops acting within each phase. The operation of such negative feedback circuits has been studied using two types of experimental input: (a) activation of pulmonary stretch receptors by lung inflation, which shortens the I phase and prolongs the E phase, and (b) electrical stimulation in the rostral pontine "pneumotaxic center" region, which can produce premature I leads to E or E leads to I switching, depending on stimulation site. These inputs produce diverse effects on discharges of various types of medullary respiratory neuron; analysis of such observations has led to hypotheses about the possible roles of different neuron populations in phase-switching.

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