Wrist sensor reveals sympathetic hyperactivity and hypoventilation before probable SUDEP

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Picard RW, Migliorini M, Caborni C, et al. (2017) Wrist sensor reveals sympathetic hyperactivity and hypoventilation before probable SUDEP. Neurology. 2017 Aug 8;89(6):633-635.

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First Paragraph: We report a probable sudden unexpected death in epilepsy (SUDEP) in a 20-year-old man wearing a smartwatch that recorded wrist motion via 3-axis accelerometer (ACC) and electrodermal activity (EDA). EDA reflects sympathetic activity without parasympathetic antagonism. The smartwatch (Empatica [Milan, Italy] Embrace, with CE Medical clearance from the European Union for seizure detection) issued an alert, received by the caregiver at 8:50 AM, indicating a probable convulsive seizure. An adult trained in cardiopulmonary resuscitation (CPR) arrived at 9:05 AM, found the patient pulseless, prone, face in pillow with mucus in his mouth, and commenced CPR for 15 minutes without recovery. The family declined autopsy.

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